Perioperative bleeding is the one of most common complications of medical procedures. Cardiovascular surgeries, liver transplantation and hepatic resection, and major orthopedic procedures, including hip and knee replacement and back surgeries, are all associated with severe bleeding. Excessive blood loss may also occur as civilian and combat trauma. As such, bleeding contributes to approximately 30% of trauma-related deaths. In 2019, there were over 4 million trauma-related-death worldwide, accounting for about 8% of the total fatalities, according to the WHO World Health Statistics report. Therefore, it is of utmost importance to prevent massive hemorrhage and hemorrhagic shock during surgical procedures and trauma intervention. On the other hand, disease-related hemorrhage, such as hereditary hemorrhagic telangiectasia, anaphylactic purpura, hemophilia, vitamin K-dependent clotting factors deficiency, as well as drug-induced bleeding, requires appropriate hemostasis interventions to effectively stop bleeding.